How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans.
BACKGROUND: Amino acid absorption in the form of di- and tripeptides is mediated by the intestinal proton-coupled peptide transporter PEPT-1 (formally OPT-2) in Caenorhabditits elegans.Transporter-deficient animals (pept-1(lg601)) Crackers show impaired growth, slowed postembryonal development and major changes in amino acid status.PRINCIPAL FINDIN